6: Effect of CD26 on Cord Blood, and Other Means to Enhance Engraftment of Hematopoietic Stem Cells
Year: 2007
Type: article
Study design: Observational Study
Abstract: GVHD were marginally lower after HLA matched or mismatched UCB transplants than after allele-matched BM.Notably, leukemia-free survival (LFS) rates at 5 years were comparable between those receiving allele matched BM (38%) and 1 locus high cell dose (41%), 1 locus low cell dose (37%) or 2 loci (33%) HLA mismatched UCB.The observed higher LFS rate (60%) after HLA matched UCB transplant requires validation in a larger cohort.These results in LFS are in part explained by differences in risks of transplant related mortality (TRM) and relapse between patient populations.Compared to allele-matched BM transplants, TRM was similar in recipients of matched and 1-locus mismatched UCB and higher in recipients of 2-loci mismatched UCB.Conversely, relapse rates were lower in recipients of UCB transplants mismatched at 2-HLA loci.These results are the first to support the use of HLA matched or mismatched UCB grafts with an adequate cell dose as a first line transplant treatment regardless of the availability of a HLA allele-matched BM donor in the setting of acute leukemia in children aged Ͻ16 years.
Author: Hal E. Broxmeyer
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2139027874