Vitamin-c Protect Ethanol Induced Apoptotic Neurodegeneration in Postnatal Rat Brain
Year: 2009
Type: article
Abstract: Objective: To evaluate ethanol effects to induced activation of caspsae-3, and to observe the protective effects of Vitamin C (vit-C) on ethanol-induced apoptotic neurodegeneration in rat cortical area of brain. Methodology: Administration of a single dose of ethanol in 7-d postnatal (P7) rats triggers activation of caspase-3 and widespread apoptotic neuronal death. Western blot analysis, cells counting and Nissl staining were used to elucidate possible protective effect of vit-C against ethanol-induced apoptotic neurodegeneration in brain. Results: The results showed that ethanol significantly increased caspase-3 expression and neuronal apoptosis. Furthermore, the co-treatment of vit-C along with ethanol showed signifi-cantly decreased expression of caspase-3 as compare to control group. Conclusion: Our findings indicate that vit-C can prevent some of the deleterious effect of ethanol on developing rat brain when given after ethanol exposure and can be used as an effective protective agent for Fetal Alcohol Syndrome (FAS).
Authors: Muhammad Imran Naseer, Najeebullah, Ikramullah Ikramullah, Hassan Zubair, Mukhtiar Hassan, Yang ByoungChul, Kim MyeongOk
Institution: Gyeongsang National University
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W2139112165