Work

A large family characterised by nocturnal sudden death.

Year: 2002

Type: article

Abstract: BACKGROUND: We recently identified a novel mutation in large family characterised by premature nocturnal sudden death. In the present paper we provide an overview of the findings in this family. METHODS: From 1958 onwards, when the first patient presented, we collected clinical data on as many family members as possible. After identification in 1998 of the underlying genetic disorder (SCN5A, 1795insD), genotyping was performed diagnostically. RESULTS: . From 1978 onwards, a pacemaker for anti-brady pacing was implanted for prevention of sudden death. In patients in whom a prophylactic pacemaker was implanted no unexplained sudden death occurred, whereas 5 sudden deaths occurred in the group of patients who did not receive a pacemaker. CONCLUSION: , Brugada syndrome and familial conduction system disease. Anti-brady pacing was successful in preventing sudden death. The mode of death is possibly bradycardic.

Source: PubMed

Authors: M P van den Berg, J W Viersma, G C M Beaufort-Krol, M Th E Bink-Boelkens, C R Bezzina, M W Veldkamp, J Brouwer, J Haaksma, J P van Tintelen, I M van Langen, A A Wouda, A A M Wilde

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2139196847

FWCI: 0.211

Cites: 23

Cited by: 8

Related to: 10