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Scc1 (CP0432) and Scc4 (CP0033) Function as a Type III Secretion Chaperone for CopN of Chlamydia pneumoniae

Year: 2011
Type: article
Abstract: The Chlamydia pneumoniae CopN protein is a member of the YopN/TyeA/InvE/MxiC family of secreted proteins that function to regulate the secretion of type III secretion system (T3SS) translocator and effector proteins. In this study, the Scc1 (CP0432) and Scc4 (CP0033) proteins of C. pneumoniae AR-39 were demonstrated to function together as a type III secretion chaperone that binds to an N-terminal region of CopN. The Scc1/Scc4 chaperone promoted the efficient secretion of CopN via a heterologous T3SS, whereas, the Scc3 chaperone, which binds to a C-terminal region of CopN, reduced CopN secretion.
DOI: 10.1128/jb.00203-11
Authors: Eugenia Silva-Herzog, Sabrina S. Joseph, Ann K. Avery, Jose A. Coba, Katerina Wolf, Kenneth A. Fields, Gregory V. Plano
Institutions: Florida International University, Uniformed Services University of the Health Sciences, MetroHealth, MetroHealth Medical Center, Case Western Reserve University, University of Miami
Language: English
Subfield: Genetics
Open Access status: green
OpenAlex ID: W2139275870
FWCI: 1.799
Cites: 41
Cited by: 34
Related to: 10