Work

Evaluation of Accessory Gene Regulator ( agr ) Group and Function in the Proclivity towards Vancomycin Intermediate Resistance in Staphylococcus aureus

Year: 2006

Type: article

Abstract: Simulated therapeutic vancomycin exposures were evaluated against agr wild-type and knockout Staphylococcus aureus groups I, II, III, and IV using an in vitro pharmacodynamic model. All agr groups developed intermediate resistance to vancomycin after subtherapeutic exposure. The free unbound fraction of the area under the concentration-time curve (fAUC/MIC) required to suppress resistance was fourfold higher (P < 0.001) in agr dysfunctional strains (112 to 169) than that in parent wild-type strains (28).

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00671-06

Authors: Brian T. Tsuji, Michael J. Rybak, Kerry L. Lau, George Sakoulas

Institutions: Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit Receiving Hospital, University at Buffalo, State University of New York, New York Medical College

Language: English

Topic: Antimicrobial Resistance in Staphylococcus

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2139349078

FWCI: 4.025

Cites: 18

Cited by: 90

Related to: 10