Work

NF-κB Fans the Flames of Lung Carcinogenesis

Year: 2010

Type: review

Abstract: This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-kappaB and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating protumorigenic roles of NF-kappaB activation in lung cancer pathogenesis. Our growing understanding of the tumor-promoting NF-kappaB downstream effector pathways could lead to the development of novel approaches for lung cancer therapy and chemoprevention.

Source: Cancer Prevention Research

DOI: 10.1158/1940-6207.capr-10-0042

Authors: Kwok-Kin Wong, Tyler Jacks, Glenn Dranoff

Institutions: Howard Hughes Medical Institute, Dana-Farber Cancer Institute, Koch Institute for Integrative Cancer Research At MIT, Massachusetts Institute of Technology

Language: English

Topic: NF-κB Signaling Pathways

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institute on Aging, National Cancer Institute