Year: 2014
Type: article
Abstract: The circadian clock is a global regulatory system that interfaces with most other regulatory systems and pathways in mammalian organisms. Investigations of the circadian clock-DNA damage response connections have revealed that nucleotide excision repair, DNA damage checkpoints, and apoptosis are appreciably influenced by the clock. Although several epidemiological studies in humans and a limited number of genetic studies in mouse model systems have indicated that clock disruption may predispose mammals to cancer, well-controlled genetic studies in mice have not supported the commonly held view that circadian clock disruption is a cancer risk factor. In fact, in the appropriate genetic background, clock disruption may instead aid in cancer regression by promoting intrinsic and extrinsic apoptosis. Finally, the clock may affect the efficacy of cancer treatment (chronochemotherapy) by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs.
Source: Biochemistry
DOI: 10.1021/bi5007354
Institution: University of North Carolina at Chapel Hill
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Awards: DNA Excision Repair and DNA Damage Checkpoints, Role of the circadian clock in melanocyte biology and UV-induced melanomagenesis, G342085443, Role of the circadian clock in melanocyte biology and UV-induced melanomagenesis, (PQD5) Predicting Anti-Cancer Efficacy through Tumor Profiling, G9000020968, UNC Center for Environmental Health and Susceptibility
OpenAlex ID: W2139669192