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Human Papillomaviruses Recruit Cellular DNA Repair and Homologous Recombination Factors to Viral Replication Centers

Year: 2012

Type: article

Abstract: Human papillomaviruses (HPV) activate the ataxia telangiectasia mutated (ATM)-dependent DNA damage response to induce viral genome amplification upon epithelial differentiation. Our studies show that along with members of the ATM pathway, HPV proteins also localize factors involved in homologous DNA recombination to distinct nuclear foci that contain HPV genomes and cellular replication factors. These studies indicate that HPV activates the ATM pathway to recruit repair factors to viral genomes and allow for efficient replication.

Source: Journal of Virology

DOI: 10.1128/jvi.00247-12

Authors: Kenric A. Gillespie, Kavi P. Mehta, Laimonis A. Laimins, Cary A. Moody

Institutions: University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center, Northwestern University

Language: English

Topic: Cervical Cancer and HPV Research

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute