Year: 2014
Type: dissertation
Abstract: __Abstract__ \n \nThe function of prorenin, the precursor of renin, remained unknown until the \ndiscovery of the (pro)renin receptor ((P)RR). (Pro)renin binding to this receptor allows \nangiotensin generation and induces signaling. Thus, (P)RR blockade will exert effects \nbeyond angiotensin suppression. Recently, the (P)RR has been identified as an accessory \nprotein of the vacuolar-type H+-ATPase, with important roles in Wnt signaling. In \naddition, transgenic animals overexpressing prorenin display the consequences of \nangiotensin generation, whereas transgenic animals overexpressing the (P)RR display an \nangiotensin-independent phenotype. Finally, both beneficial and deleterious effects have \nbeen described following treatment with the (P)RR antagonist ‘handle region peptide’ \n(HRP), while a (P)RR knockout in cardiomyocytes is lethal. This review highlights the \nlatest findings in the (P)RR area, focusing on cardiovascular and renal pathology. It \ncritically addresses the possibility that (pro)renin acts as an agonist of this receptor in \nvivo, and discusses the efficacy of HRP. Conclusions are that convincing evidence for \n(pro)renin-(P)RR interaction in vivo is currently lacking and, thus, that the concept \nof HRP exerting beneficial effects by blocking such interaction remains to be proven.
Author: Xifeng Lu
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Novartis Pharma
OpenAlex ID: W2139862978