Localization of a major susceptibility locus influencing preterm birth
Year: 2013
Type: article
Study design: Observational Study
Abstract: Preterm birth (PTB) is a complex trait, but little is known regarding its major genetic determinants. The objective of this study is to localize genes that influence susceptibility to PTB in Mexican Americans (MAs), a minority population in the USA, using predominantly microfilmed birth certificate-based data obtained from the San Antonio Family Birth Weight Study. Only 1302 singleton births from 288 families with information on PTB and significant covariates were considered for genetic analysis. PTB is defined as a childbirth that occurs at <37 completed weeks of gestation, and the prevalence of PTB in this sample was 6.4%. An ∼10 cM genetic map was used to conduct a genome-wide linkage analysis using the program SOLAR. The heritability of PTB was high (h(2) ± SE: 0.75 ± 0.20) and significant (P = 4.5 × 10(-5)), after adjusting for the significant effects of birthweight and birth order. We found significant evidence for linkage of PTB (LOD = 3.6; nominal P = 2.3 × 10(-5); empirical P = 1.0 × 10(-5)) on chromosome 18q between markers D18S1364 and D18S541. Several other chromosomal regions (2q, 9p, 16q and 20q) were also potentially linked with PTB. A strong positional candidate gene in the 18q linked region is SERPINB2 or PAI-2, a member of the plasminogen activator system that is associated with various reproductive processes. In conclusion, to our knowledge, perhaps for the first time in MAs or US populations, we have localized a major susceptibility locus for PTB on chromosome 18q21.33-q23.
Source: Molecular Human Reproduction
Authors: G. Chittoor, V. S. Farook, S. Puppala, S. P. Fowler, J. Schneider, T. D. Dyer, S. A. Cole, J. L. Lynch, J. E. Curran, L. Almasy, J. W. MacCluer, A. G. Comuzzie, D. E. Hale, R. S. Ramamurthy, D. J. Dudley, E. K. Moses, R. Arya, D. M. Lehman, C. P. Jenkinson, B. S. Bradshaw, R. A. DeFronzo, J. Blangero, R. Duggirala
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1111185181, Genetics of Birth Weight in Mexican Americans, G1700758416, G2169778925, GENERAL CLINICAL RESEARCH CENTER, EXTRAMULAR RESEARCH FACILITIES CONSTRUCTION, GENETIC EPIDEMIOLOGY OF NIDDM IN MEXICAN AMERICANS, G4066245281, Genetics of Atherosclerosis in Mexican Americans, NIDDM Susceptibility Genes in Mexican Americans, High Performance Computing System for Human Genomics, G518778165, Genetics of Gallbladder Disease in Mexican Americans, MOLECULAR AND BIOCHEMICAL GENETICS LABORATORY RENOVATION, G8483267663, G84885695, QUANTITATIVE TRAIT LOCUS MAPPING IN HUMAN PEDIGREES
OpenAlex ID: W2139870529