ZOOMING IN: a new high‐resolution gene expression atlas of the brain
Year: 2007
Type: article
Abstract: If you walk through a laboratory at the Salk Institute, all the people working in it look fairly similar: two legs, a head and so on. However, it is only through a more detailed analysis that one could reveal the differences between the first year graduate student (nervously pipetting) and the well-respected principal investigator (PI) (editing manuscripts). Analogous to this, how can we discriminate diverse neuronal populations (e.g. graduate student versus PI) and even understand their function in the adult brain? Genome-wide, unbiased gene expression studies using DNA microarrays or serial analyses of gene expression have created a tremendous amount of data defining tissue-specific and even region-specific gene expression in mammals (Lockhart et al, 1996; Datson et al, 2001; Lewandowski and Small, 2005). In other words, the ‘laboratory ’ (in analogy to organs, e.g., the
Source: Molecular Systems Biology
DOI: 10.1038/msb4100122
Authors: Sebastian Jessberger, Fred H Gage
Institution: Salk Institute for Biological Studies
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $7,990
OpenAlex ID: W2139938743