Work

Interrelationships of Circulating Tumor Cells with Metastasis and Thrombosis: Role of MicroRNAs

Year: 2014

Type: article

Abstract: Metastasis and thrombosis are serious threats to cancer patients and generally associated with poor prognosis. The elusive mechanisms underlying the pathogenesis of metastasis and thrombosis have been subjects of extensive investigations. The presence of circulating tumor cells (CTCs) is closely related to tumor metastasis, and these cells play an important role in thrombosis in cancer patients. In this review, we describe the latest findings on the role of CTCs in tumor metastasis and cancer-related thrombosis and the regulatory role of microRNAs in CTCs and thrombosis. Additionally, we discuss anticoagulant-based strategies for the prevention of thrombosis and reduction of cancer metastasis and the potential to translate current knowledge on these strategies to the treatment of cancer.

Source: Current Pharmaceutical Design

DOI: 10.2174/1381612820666140128220152

Authors: Junli Xue, Victoria Xie, Peipei Wang, Jiujie Cui, Yong Gao, Zhimin Lu

Institutions: Tongji University, Shanghai East Hospital, The University of Texas MD Anderson Cancer Center

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Cancer Institute, National Institute of Neurological Disorders and Stroke