Work

Measuring Rate Constants for the Reaction of Hypochlorous Acid and Biologically Relevant Molecules

Year: 2012

Type: article

Abstract: Hypochlorous acid (HOCl) is a neutrophil-derived oxidant that is used to kill invading pathogens. Since HOCl reacts indiscriminately with biological molecules, such as amino acids, excess or misplaced production of HOCl can cause host tissue damage. Methionine (Met), one of only two naturally occurring sulfur amino acids, reacts fast with HOCl making it one of the first targets. The mechanism for this reaction is not well known but is assumed to go through a chlorosulfonium intermediate to form methionine sulfoxide (MetO), and then methionine sulfone (MetO2).

Source: SHAREOK (University of Oklahoma; Oklahoma State University; Central Oklahoma University)

Author: Jennifer L. Beal

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W214013713

FWCI: 0.133

Cites:

Cited by: 2

Related to: 10