NMR in physiology and biomedicine, Robert J. Gillies, Ph.D. ed., Academic Press, San Diego, California, 1994. 471 pp. $95.00
Year: 1995
Type: book-review
Abstract: The editor of this book has brought together a distinguished group of internationally recognized experts to produce a thorough review of the use of nuclear magnetic resonance approaches to investigate biomedical problems.This book is written at a level accessible to most readers and should prove valuable to anyone interested in obtaining a state-of-the-art overview of biomedical NMR.This volume could easily serve as a textbook for a course on biomedical NMR in graduate school or medical school.I also highly recommend to anyone working in the field of biomedical NMR to read the outstanding global perspective offered by Robert Shulman in the foreword of the book.This book consists of 26 chapters.In Chapter 1, an introduction to NMR is presented, which includes the NMR phenomenon and basic principles of in vivo MRS and MRI techniques.Chapter 2 introduces basic imaging methods with an emphasis on diffusion, perfusion, and flow imaging.An overview of the use of MRI to evaluate tissue microcirculation and perfusion is presented in Chapter 3. Chapter 4 summarizes the current understanding of the processes that contribute to 1/T, and 1/T2 at the molecular and anatomical levels, provides a perspective on features of chemical structure to guide MRI contrast agent development, and describes the concepts and principles of relaxation behavior of the water protons of tissue.Chapter 5 is devoted to the physiochemical principles that influence magnetopharmaceuticals.The applications of NMR microscopy to study tumors, kidney, and neurobiology through measurements of restricted diffusion and small metabolites is discussed in Chapter 6.The principles and mechanisms involved in magnetization transfer contrast (MTC) MRI are explored in Chapter 7 along with a discussion of the experimental difficulties associated with quantitative clinical MTC.Highlights of MTC applications which may have practical clinical utility are also presented.Chapter 8 discusses functional imaging of the brain by NMR and focuses primarily on the blood oxygenation level-dependent (BOLD) method used for functional brain mapping.The concepts and methods employed to obtain spatially localized in vivo MR spectra are included in Chapter 9. Chapter 10 provides a brief introduction into MR spectroscopic imaging and an overview of its applications emphasizing the brain.In Chapter 11, the methods and theory of diffusion spectroscopy is presented along with recent in vivo and ex vivo results.A review of the use of MRM MI36 (1995)
Source: Magnetic Resonance in Medicine
Author: Brian D. Ross
Institution: University of Michigan
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2140173022