Work

Ca 2+ permeable AMPA receptors switch allegiances: mechanisms and consequences

Year: 2011

Type: article

Abstract: The subunit composition of synaptic AMPA receptors can undergo dynamic changes during physiological functioning and under pathological conditions. This switch in AMPA receptor phenotype involves changes in the level of GluA2 subunits that are mediated via regulated AMPA receptor trafficking, modification of local protein synthesis and altered gene transcription of GluA2 subunits. Incorporation of the GluA2 subunits into an AMPA receptor alters a number of key biophysical properties, including Ca(2+) permeability and the waveform of the synaptic current. These changes alter the ability of synaptic currents to evoke an action potential and therefore have a profound effect on the computational capability of individual neurons and thus the output of neuronal circuits.

Source: The Journal of Physiology

DOI: 10.1113/jphysiol.2011.213926

Authors: Siqiong June Liu, Iaroslav Savtchouk

Institution: Louisiana State University Health Sciences Center New Orleans

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: Cellular Mechanisms Underlying the Long-term Potentiation of GABA Release, G2422639787