Work

Rho GTPases in hematopoietic stem cell functions

Year: 2009

Type: article

Abstract: PURPOSE OF REVIEW: Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in hematopoietic stem cells (HSCs) and progeny of these cells. Rho GTPases are now known to be crucial in HSCs response to hematopoietic microenvironment cues. This article will review the known HSC functions, which are regulated by Rho GTPases. RECENT FINDINGS: This review analyzes the latest data on how different Rho GTPases control adhesion, migration, retention, proliferation, survival, senescence and oncogenic transformation of HSCs and relates these new findings to the physiological functions of these cells. SUMMARY: The development of small molecule inhibitors with ability to interfere Rho GTPase activation by guanine nucleotide exchange factors offers new therapeutic strategies to manipulate the function of HSCs.

Source: Current Opinion in Hematology

DOI: 10.1097/moh.0b013e32832c4b80

Authors: Jose A Cancelas, David A Williams

Institutions: Cincinnati Children's Hospital Medical Center, University of Cincinnati Medical Center, Boston Children's Hospital, Harvard University, Harvard Stem Cell Institute

Language: English

Topic: Hematopoietic Stem Cell Transplantation

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases