Work

Various mechanisms in cyclopeptide production from precursors synthesized independently of non-ribosomal peptide synthetases

Year: 2011

Type: review

Abstract: An increasing number of cyclopeptides have been discovered as products of ribosomal synthetic pathway. The biosynthetic study of these cyclopeptides has revealed interesting new mechanisms for cyclization. This review highlighted the recent discoveries in cyclization mechanisms for cyclopeptides synthesized independently of non-ribosomal peptide synthetases, including endopeptidase-catalyzed cyclization, intein-mediated cyclization, and peptide synthetase-catalyzed cyclization. This information may help to design hybrid ribosomal and non-ribosomal biosynthetic systems to produce novel cyclopeptides with various bioactivities.

Source: Acta Biochimica et Biophysica Sinica

DOI: 10.1093/abbs/gmr062

Authors: Wenyan Xu, Liling Li, Liangcheng Du, Ninghua Tan

Institutions: Kunming Institute of Botany, Chinese Academy of Sciences, University of Nebraska–Lincoln

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Center for Research Resources

Awards: G3627422483, EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION