Work

Cell-free fetal DNA testing for fetal aneuploidy and beyond: clinical integration challenges in the US context

Year: 2012

Type: article

Abstract: The recent release of new, non-invasive prenatal tests for fetal aneuploidy using cell-free fetal DNA (cffDNA) has been hailed as a revolution in prenatal testing and has triggered significant commercial interest in the field. Ongoing research portends the arrival of a wide range of cffDNA tests. However, it is not yet clear how these tests will be integrated into well-established prenatal testing strategies in the USA, as the timing of such testing and the degree to which new non-invasive tests will supplement or replace existing screening and diagnostic tools remain uncertain. We argue that there is an urgent need for policy-makers, regulators and professional societies to provide guidance on the most efficient and ethical manner for such tests to be introduced into clinical practice in the USA.

Source: Human Reproduction

DOI: 10.1093/humrep/des286

Authors: M. Allyse, L. C. Sayres, J. S. King, M. E. Norton, M. K. Cho

Institutions: Stanford University, University of California, San Francisco, University of California Hastings College of the Law, Stanford Medicine

Language: English

Topic: Prenatal Screening and Diagnostics

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: National Institutes of Health, National Human Genome Research Institute, National Center for Research Resources, National Center for Advancing Translational Sciences