Work

Asymmetric Methods for the Synthesis of Flavanones, Chromanones, and Azaflavanones

Year: 2011

Type: article

Abstract: Flavanones, chromanones, and related structures are privileged natural products that display a wide variety of biological activities. Although flavanoids are abundant in nature, there are a limited number of available general and efficient synthetic methods for accessing molecules of this class in a stereoselective manner. Their structurally simple architectures belie the difficulties involved in installation and maintenance of the stereogenic configuration at the C2 position, which can be sensitive and can undergo epimerization under mildly acidic, basic, and thermal reaction conditions. This review presents the methods currently used to access these related structures. The synthetic methods include manipulation of the flavone/flavanone core, carbon-carbon bond formation, and carbon-heteroatom bond formation.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.201101228

Authors: Antoinette E. Nibbs, Karl A. Scheidt

Institutions: Northwestern University, Chemistry of Life Processes Institute

Language: English

Topic: Synthesis of Organic Compounds

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

Open Access status: green

Funder: National Cancer Institute

Awards: G219817190, G3757098364, SPORE in Prostate Cancer