Work

Functional Simian Virus 40 T Antigen Is Expressed in Hybrid Cells Having Finite Proliferative Potential

Year: 1987

Type: article

Abstract: Simian virus 40-transformed human cells fused with other independently derived simian virus 40-transformed cells and tumor-derived cells containing activated H-ras and N-ras oncogenes yielded hybrids capable of indefinite division. Fusions with various other immortal cells yielded hybrids that had limited division potential. T antigen expressed in limited-division hybrids was functional for the induction of cellular DNA synthesis.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.7.4.1541

Authors: O M Pereira-Smith, J R Smith

Language: English

Topic: Polyomavirus and related diseases

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute on Aging

Awards: G1164276947, G5916975089