Work

The Effect of Adenovirus-Mediated Gene Expression of FHIT in Small Cell Lung Cancer Cells

Year: 2011

Type: article

Abstract: The candidate tumor suppressor fragile histidine traid (FHIT) is frequently inactivated in small cell lung cancer (SCLC). Mutations in the p53 gene also occur in the majority of SCLC leading to the accumulation of the mutant protein. Here we evaluated the effect of FHIT gene therapy alone or in combination with the mutant p53-reactivating molecule, PRIMA-1(Met)/APR-246, in SCLC. Overexpression of FHIT by recombinant adenoviral vector (Ad-FHIT)-mediated gene transfer in SCLC cells inhibited their growth by inducing apoptosis and when combined with PRIMA-1(Met)/APR-246, a synergistic cell growth inhibition was achieved.

Source: Cancer Investigation

DOI: 10.3109/07357907.2011.626475

Authors: Roza Zandi, Kai Xu, Hans S. Poulsen, Jack A. Roth, Lin Ji

Institutions: The University of Texas MD Anderson Cancer Center, University of Copenhagen, Copenhagen University Hospital

Language: English

Topic: Virus-based gene therapy research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute