Application of the Rosner-Colditz Risk Prediction Model to Estimate Sexual Orientation Group Disparities in Breast Cancer Risk in a U.S. Cohort of Premenopausal Women
Year: 2012
Type: article
Abstract: BACKGROUND: Lesbian and bisexual women may be at greater risk of breast cancer than heterosexual women during the premenopausal period due to disparities in risk factors. METHODS: With 16 years of prospective data from a large cohort of U.S. women ages 25-58 years, we conducted a breast cancer risk assessment for 87,392 premenopausal women by applying the Rosner-Colditz biomathematical risk prediction model to estimate breast cancer risk based on known risk factors. On the basis of each woman's comprehensive risk factor profile, we calculated the predicted 1-year incidence rate (IR) per 100,000 person-years and estimated incidence rate ratios (IRR) and 95% confidence intervals (CI) for lesbian and bisexual women compared with heterosexual women. RESULTS: A total of 87,392 premenopausal women provided 1,091,871 person-years of data included in analyses. Mean predicted 1-year breast cancer IRs per 100,000 person-years for each sexual orientation group were heterosexual, 122.55; lesbian, 131.61; and bisexual, 131.72. IRs were significantly elevated in both lesbian (IRR, 1.06; 95% CI, 1.06-1.06) and bisexual (IRR, 1.10; 95% CI, 1.10-1.10) women compared with heterosexual women. CONCLUSIONS: Our findings suggest that both lesbian and bisexual women have slightly elevated predicted breast cancer incidence compared with heterosexual women throughout the premenopausal period. IMPACT: Health professionals must ensure that breast cancer prevention efforts are reaching these women. As more health systems around the country collect data on patient sexual orientation, the National Cancer Institute's SEER cancer registry should add this information to its data system to monitor progress in reducing sexual orientation-related disparities in cancer incidence and mortality.
Language: English
Topic: Cancer Risks and Factors
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: National Institutes of Health, U.S. Public Health Service, National Institute on Aging, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Chronic Disease Prevention and Health Promotion, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: HYPERTENSIVE DISORDERS OF PREGNANCY, G1189012647, G1447295899, G1477837645, Risk Factors for Endometriosis, ANALGESIC USE AND THE RISK OF CHRONIC RENAL FAILURE, Cohort Study of Genetic Susceptibility to Breast Cancer, G2841009649, PREMENOPAUSAL HORMONE LEVELS AND RISK OF BREAST CANCER, G3602225402, CHRONIC LIFE STRESS AND INCIDENT ASTHMA IN ADULT WOMEN, G4537316941, G4666650047, G5362739798, G5551855518, RANDOMIZED TRIAL OF FOLATE AND COLORECTAL ADENOMA, G6425101868, G6548527268, Risk Factors for Breast Cancer in Younger Nurses, Risk Factors for Recurrent Nephrolithiasis, G8005855904, Premenopausal Hormone Levels and Risk of Breast Cancer, G8821123181
OpenAlex ID: W2140388540