Work

Disordered Lipid Metabolism and the Pathogenesis of Insulin Resistance

Year: 2007

Type: review

Abstract: Although abnormal glucose metabolism defines type 2 diabetes mellitus (T2DM) and accounts for many of its symptoms and complications, efforts to understand the pathogenesis of T2DM are increasingly focused on disordered lipid metabolism. Here we review recent human studies exploring the mechanistic links between disorders of fatty acid/lipid metabolism and insulin resistance. As "mouse models of insulin resistance" were comprehensively reviewed in Physiological Reviews by Nandi et al. in 2004, we will concentrate on human studies involving the use of isotopes and/or magnetic resonance spectroscopy, occasionally drawing on mouse models which provide additional mechanistic insight.

Source: Physiological Reviews

DOI: 10.1152/physrev.00024.2006

Authors: David B. Savage, Kitt Falk Petersen, Gerald I. Shulman

Institutions: Howard Hughes Medical Institute, Yale University

Language: English

Topic: Diabetes, Cardiovascular Risks, and Lipoproteins

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Wellcome Trust, National Institute on Aging, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources