Effect of Nateglinide on Early Insulin Response after Sucrose Loading in OLETF Rats (Original)
Year: 2003
Type: article
Abstract: We studied the effects of nateglinide on early insulin secretion after sucrose loading in spontaneously diabetic Otsuka Long-Evans Tokushima Fatty rats.Six 8-week-old and 6 16-week-old OLETF rats were fasted for 17 hours, then given 50 mg/kg of oral nateglinide.Rats in two agematched control groups of 6 rats each were given 0.5% oral methylcellulose.Immediately after these administrations,all groups received an oral loading dose of of sucrose(2.5g/ kg).Nateglinide significantly increased insulin levels and decreased blood glucose levels.Insulin levels returned to near control levels at 60 and 180 minutes in 8-and 16-week-old rats, respectively.Subsequently, four groups (n＝6)of 24-week-old OLETF rats were given the following drugs orally after a 17hour fast : 50 mg/kg of nateglinide; 4 mg/kg of glibenclamide; 0.2 mg/kg of voglibose; or 0.5% methylcellulose (control), then immediately received 2.5 g/kg loading dose of oral sucrose.Both nateglinide and voglibose significantly decreased glucose levels at 30,60, and 120 minutes; and glibenclamide decreased glucose levels at 120 minutes.Insulin levels after sucrose loading in 24week-old rats did not increase in the nateglinide group, continued to increase until 360 minutes in the glibenclamide group, and were finally lower in the voglibose group.Fast-acting insulin secretagogues, such as nateglinide and α-glucosidase inhibitors, may be more appropriate than glibenclamide for patients with early type 2 diabetes who show reduced early insulin secretion and delayed hyperinsulinemia after glucose loading.
Authors: Yutaka Mori, Hideaki Komiya, Naoko Tajima
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2140503143