Work

Selection and Amplification of a Catalyst from a Dynamic Combinatorial Library

Year: 2003

Type: article

Abstract: Amplification of the fittest: A dynamic combinatorial library (DCL) of macrocyclic disulfides in water was exposed to a transition-state analogue (TSA) for a Diels–Alder reaction. Two receptors were selected and amplified, of which one binds to the TSA more strongly than to the starting material and catalyzes the Diels–Alder reaction (see scheme).

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200390326

Authors: Barbara Brisig, Jeremy K. M. Sanders, Sijbren Otto

Institutions: University of Basel, University of Cambridge

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Royal Society, European Commission, Engineering and Physical Sciences Research Council

OpenAlex ID: W2140815785

FWCI: 10.96

Cites: 32

Cited by: 166

Related to: 10