Year: 2005
Type: article
Study design: Observational Study
Abstract: A raised white cell count (WCC) suggests chronic low-grade inflammation and has been described in patients with impaired fasting glucose (IFG) and type II diabetes mellitus (T2DM). It is associated with increased cardiovascular risk. To investigate this further a 3-year study of white, non-smoking, normoglycaemic men with treated hypertension (target<140/90) was performed. The aim of this study was to investigate the link between insulin resistance (IR), WCC and future development of IFG and T2DM. IR was calculated using the homeostasis model assessment (HOMA-IR) and correlated with routinely measured clinical variables. White cell count was measured annually for 3 years. 106 patients were recruited and of these 36 had a HOMA-IR <1.5 (group A) and 70 had a HOMA-IR >1.5 (group B). The mean BP, type and number of antihypertensive medication didn’t differ between the groups. Group B patients had a higher white cell count (p<0.02), BMI (p<0.04) and triglyceride (p<0.005) but there was substantial overlap of these risk factors. By 1 year, (4/36) 11% of group A and (19/70) 27% of group B developed IFG (p<0.04). After 3-years, none from group A and (3/19) 16% of group B who had developed and IFG by 1 year were confirmed as having T2DM. IR is an inflammatory condition and leads to IFG, T2DM and increases cardiovascular risk. See Table 1. Patient characteristics; median (range) *p < 0.0001 †p < 0.003 ¥p < 0.02 #p < 0.04 vs. group A
Source: American Journal of Hypertension
Authors: M MOHTESHAMZADEH, R WILKINSON, S THOMAS
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2140834282