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Salivary Immunoglobulins and Prevalent Coronary Artery Disease

Year: 2010
Type: article
Study design: Observational Study
Abstract: Previous studies examined the serum immunoglobulin levels in relation to coronary artery disease (CAD). We hypothesized that the salivary immunoglobulins might better estimate oral infections in this relationship. Multivariate logistic regression analyses utilizing the data from 256 angiographically confirmed CAD patients and 250 non-CAD individuals that controlled for age, sex, smoking, diabetes, total/HDL cholesterol ratio, hypertension, and education revealed the trends that salivary IgA was positively and salivary IgG was inversely associated with CAD. The odds ratios (OR) of each increasing quartile of salivary IgA were 1.00 (first and second quartiles combined), 1.97, and 1.37 (p-value for trend = 0.06), while those for salivary IgG were 1.00, 0.77, 0.60, and 0.51 (p-value for trend = 0.02). Additionally, salivary IgA correlated positively with C-reactive protein and Asymptotic Dental Score (dental infection score), while IgG was inversely associated with these inflammation markers. Salivary IgA warrants further studies to confirm its role in the risk assessment of CAD.
DOI: 10.1177/0022034509359884
Authors: S. Janket, J.H. Meurman, A.E. Baird, M. Qvarnström, P. Nuutinen, L.K. Ackerson, J. Hong, P. Muthukrishnan, T.E. Van Dyke
Institutions: Boston University, State University of New York, University of Helsinki, SUNY Downstate Health Sciences University, Helsinki University Hospital, Kuopio University Hospital
Language: English
Subfield: Periodontics
Field: Dentistry
Open Access status: green
Funders: American Heart Association, Helsingin ja Uudenmaan Sairaanhoitopiiri, European Atherosclerosis Society, National Institutes of Health, U.S. Public Health Service, National Institute of Dental and Craniofacial Research
OpenAlex ID: W2140919441
FWCI: 1.693
Cites: 31
Cited by: 19
Related to: 10