IC‐P‐107: Whither the hippocampus?: FDG‐PET hippocampal hypometabolism in Alzheimer's disease revisited
Year: 2012
Type: article
Abstract: The hippocampus is a widely recognized area of early change in Alzheimer's disease (AD), yet voxel-wise analyses of FDG PET activity differences between AD and cognitively normal (CN) controls have consistently failed to identify hippocampal hypometabolism. In this paper we propose a high dimensional PET-specific analysis framework to determine if important hippocampal metabolic FDG PET activity differences between AD and CN subjects are embedded in the Jacobian information generated during spatial normalization. Resting FDG PET data was obtained from 102 CN and 92 AD participants from the Alzheimer's disease Neuroimaging Initiative database. A PET study-specific template was constructed using symmetric diffeomorphic registration. Spatially normalized raw FDG maps, Jacobian determinant maps, and modulated maps were generated for all subjects. Statistical parametric mapping and tensor-based morphometry (TBM) was performed comparing AD to CN. Whole brain spatially normalized raw FDG maps demonstrated robust hypometabolism in cingulate gyrus and bilateral parietal areas. No hippocampal differences were present, except on region of interest-based analyses with a hippocampal mask. Whole brain modulated maps demonstrated robust bilateral hippocampal hypometabolism, and some hypometabolism in the posterior cingulate (Figure 1). TBM demonstrated robust hippocampal differences only.
Source: Alzheimer s & Dementia
Authors: Christopher Whitlow, Joseph Maldjian
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2140943614