Year: 1998
Type: article
Abstract: A research program has applied the tools of synthetic organic chemistry to systematically modify the structure of DNA and RNA oligonucleotides to learn more about the chemical principles underlying their ability to store and transmit genetic information. Oligonucleotides (as opposed to nucleosides) have long been overlooked by synthetic organic chemists as targets for structural modification. Synthetic chemistry has now yielded oligonucleotides with 12 replicatable letters, modified backbones, and new insight into why Nature chose the oligonucleotide structures that she did.
Source: Pure and Applied Chemistry
Authors: S. A. Benner, T. R. Battersby, Bernd Eschgfäller, Daniel Hutter, J. T. Kodra, Stefan Lutz, Tuncer Arslan, D. K. Bäschlin, M. Blättler, Martin Egli, Christophe Hammer, H. A. Held, Jennifer Horlacher, Zh. Huang, Birgitte Hyrup, T. F. Jenny, S. C. Jurczyk, H. A. König, U. von Krosigk, M. J. Lutz, L. J. MacPherson, S. E. Moroney, E. Müller, K. P. Nambiar, J. A. Piccirilli, C. Y. Switzer, J. J. Vögel, C. Richert, A. L. Roughton, J. Schmidt, K. C. Schneider, J. Stackhouse
Institutions: University of Florida, ETH Zurich
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W2141053955