OpenAlex | Nelfinavir Down-regulates Hypoxia-Inducible Factor 1α and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy

Nelfinavir Down-regulates Hypoxia-Inducible Factor 1α and VEGF Expression and Increases Tumor Oxygenation: Implications for Radiotherapy

Work

Year: 2006

Type: article

Abstract: The phosphatidylinositol 3-kinase (PI3K)/Akt pathway can increase vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1α (HIF-1α) expression. We examined the effect of nelfinavir, ... more

Source: Cancer Research

Authors Nabendu Pore, Anjali Gupta, George J. Cerniglia, Zibin Jiang, Eric J. Bernhard +4 more

Institutions University of Pennsylvania, John Radcliffe Hospital, University of Oxford

Cites: 47

Cited by: 150

Related to: 10

FWCI: 4.824

Citation percentile (by year/subfield): 91.79

Topic: Cancer, Hypoxia, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Sustainable Development Goal Good health and well-being

Open Access status: green