Work

Primary Peptide Folding Dynamics Observed with Ultrafast Temperature Jump

Year: 2009

Type: article

Abstract: Fastest folding: An ultrafast laser temperature jump (T-jump) induces folding and unfolding of Wh5 (see picture), the shortest possible α-helical peptide. Using time-resolved fluorescence spectroscopy, the folding time of this peptide was found to span from less than one nanosecond to a few nanoseconds, redefining the meaning of ultrafast dynamics in protein and peptide folding.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200900513

Authors: Omar F. Mohammed, Gouri S. Jas, Milo M. Lin, Ahmed H. Zewail

Institutions: California Institute of Technology, Baylor University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: Ultrafast Electron Cryomicroscopy of Single Protein Particles