Work

Animal Models of Focal and Global Cerebral Ischemia

Year: 2003

Type: review

Abstract: The use of appropriate animal models is essential to predict the value and effect of therapeutic approaches in human subjects. Focal (stroke) and global (cardiac arrest) cerebral ischemia represents diseases that are common in the human population. Stroke and cardiac arrest, which are major causes of death and disability, affect millions of individuals around the world and are responsible for the leading health care costs of all diseases. Understanding the mechanisms of injury and neuroprotection in these diseases is critical if we are ever to learn new target sites to treat ischemia. There are many animal models available to investigate injury mechanisms and neuroprotective strategies. This review summarizes many (but not all) small and large animal models of focal and global cerebral ischemia and discusses their advantages and disadvantages.

Source: ILAR Journal

DOI: 10.1093/ilar.44.2.85

Author: R. J. Traystman

Institutions: Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Acute Ischemic Stroke Management

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Johns Hopkins University, National Institutes of Health, National Institute of Neurological Disorders and Stroke