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Mechanisms of Sudden Cardiac Death

Year: 2015
Type: review
Abstract: Ventricular arrhythmia is the leading cause of sudden cardiac death (SCD). Deranged cardiac metabolism and abnormal redox state during cardiac diseases foment arrhythmogenic substrates through direct or indirect modulation of cardiac ion channel/transporter function. This review presents current evidence on the mechanisms linking metabolic derangement and excessive oxidative stress to ion channel/transporter dysfunction that predisposes to ventricular arrhythmias and SCD. Because conventional antiarrhythmic agents aiming at ion channels have proven challenging to use, targeting arrhythmogenic metabolic changes and redox imbalance may provide novel therapeutics to treat or prevent life-threatening arrhythmias and SCD.
DOI: 10.1161/circresaha.116.304691
Institutions: University of Wisconsin–Madison, National Taiwan University, Brown University, Providence VA Medical Center, National Taiwan University Hospital, Lifespan
Language: English
Field: Medicine
Open Access status: green
Awards: Mechanisms of sulfonylurea receptor mediated cardiomyopathy, Metabolic Regulation of Sodium Channels, G5086602040, Na+ Channel mRNA Regulation in Heart Failure, Molecular Regulation of Cardiac KATP Channels in Ischemia, Cellular and clinical phenotypes of novel SCN5a mutations
OpenAlex ID: W2141265094
FWCI: 1.696
Cites: 275
Cited by: 134
Related to: 10