Year: 2002
Type: review
Abstract: Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites. Although their composition and locations relative to their cognate genes are different, LCRs have been described in a broad spectrum of mammalian gene systems, suggesting that they play an important role in the control of eukaryotic gene expression. The discovery of the LCR in the beta-globin locus and the characterization of LCRs in other loci reinforces the concept that developmental and cell lineage-specific regulation of gene expression relies not on gene-proximal elements such as promoters, enhancers, and silencers exclusively, but also on long-range interactions of various cis regulatory elements and dynamic chromatin alterations.
Source: Blood
Authors: Qiliang Li, Kenneth R. Peterson, Xiangdong Fang, George Stamatoyannopoulos
Institutions: University of Washington, University of Kansas Medical Center
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
Awards: G1090662316, Cellular Mechanisms of HB F Regulation, Mechanism of Gamma-Globin Gene Activation in the Adult, Molecular control of fetal G-globin gene expression, G5643018289, Locus-linked Regulatory Motifs of Globin Gene Switching, Locus-linked Regulatory Motifs of Globin Gene Switching, G8740332745
OpenAlex ID: W2141340108