Work

Phase Difference Between Low-frequency Oscillations of Cerebral Deoxy- and Oxy-hemoglobin Concentrations During a Mental Task

Year: 2011

Type: article

Abstract: Hemodynamic low-frequency (~0.1 Hz) spontaneous oscillations as detected in the brain by near-infrared spectroscopy have potential applications in the study of brain activation, cerebral autoregulation, and functional connectivity. In this work, we have investigated the phase lag between oscillations of cerebral deoxy- and oxy-hemoglobin concentrations in the frequency range 0.05-0.10 Hz in a human subject during a mental workload task. We have obtained a measure of such phase lag using two different methods: (1) phase synchronization analysis as used in the theory of chaotic oscillators and (2) a novel cross-correlation phasor approach. The two methods yielded comparable initial results of a larger phase lag between low-frequency oscillations of deoxy- and oxy-hemoglobin concentrations during mental workload with respect to a control, rest condition.

Source: Journal of Innovative Optical Health Sciences

DOI: 10.1142/s1793545811001332

Authors: ANGELO SASSAROLI, FENG ZHENG, MICHELE PIERRO, PETER R. BERGETHON, SERGIO FANTINI

Institution: Tufts University

Language: English

Topic: Optical Imaging and Spectroscopy Techniques

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, National Institutes of Health, National Institute of Neurological Disorders and Stroke