Work

Transcriptional Modulator NusA Interacts with Translesion DNA Polymerases in Escherichia coli

Year: 2008

Type: article

Abstract: NusA, a modulator of RNA polymerase, interacts with the DNA polymerase DinB. An increased level of expression of dinB or umuDC suppresses the temperature sensitivity of the nusA11 strain, requiring the catalytic activities of these proteins. We propose that NusA recruits translesion DNA synthesis (TLS) polymerases to RNA polymerases stalled at gaps, coupling TLS to transcription.

Source: Journal of Bacteriology

DOI: 10.1128/jb.00941-08

Authors: Susan E. Cohen, Veronica G. Godoy, Graham C. Walker

Institutions: Massachusetts Institute of Technology, Northeastern University

Language: English

Topic: DNA Repair Mechanisms

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: National Institutes of Health, National Cancer Institute, National Institute of Environmental Health Sciences

Awards: G1148400999, G2635135421, MIT Center for Environmental Health Sciences, Mutagenesis and Repair of DNA, G9000300833