Year: 1999
Type: dissertation
Study design: Clinical Trial
Abstract: CHAPTER ICW1'lLR J GLI'ERAL ].\7ROD/XTTOX SGA 13 s~ret)' ~r GH treahllellt Using supraphysiological GH dosages for a long period during childhood, we wanted to know if GH treatment would have side-effects.Therefore, we evaluated the development of the body proportions of short children born SGA before and during six years of GH treatment.In addition, we assessed the effect of GH on carbohydrate metabolism during six years of treatment.Furthermore, the body composition, blood pressure, and lipids were evaluated during long-term GH treatment.Outline of the thesis, part "Children "ith short stature born SGA"This part of the doctoral disscrtation givcs thc rcsults of thc randomizcd, double-blind dose-response study on GH treatment in 79 children with short stature born SGA either with or without abnormalities of the GH/IGFaxis.This study was started in 1991.Preliminary results concerning the first years of the study period were reported in the thesis ofW de Waal entitled "Influcncing the extremes of growth", Rotterdam 1996.Chapter 2 describes the efiects of 5 years ofGH treatment on height, bone maturation, predicted final height, IGF-I, and IGFBP3 levels ill short children born SGA.Chaptcr 3 describes the body proportions of short children born SGA before and during six years of GH treatment.Chapter 4 presents the effect of GH treatment on carbohydrate mctabolism during six years of GH treatment.Chapter 5 gives the results of body composition, blood pressure, and lipids during long-term GH treatment.Chapter 6 discusses the significance of the presented data as such and in the relation to the current literahlre.Our final conclusions are listed and recommendations for fuhlre research are given.Finally, Chapter 7 summarizes this dissertation in English as well as in Dutch.References I.
Author: Theo Sas
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2141504668