Work

Calcineurin Localizes to the Hyphal Septum in Aspergillus fumigatus : Implications for Septum Formation and Conidiophore Development

Year: 2008

Type: article

Abstract: A functional calcineurin A fusion to enhanced green fluorescent protein (EGFP), CnaA-EGFP, was expressed in the Aspergillus fumigatus DeltacnaA mutant. CnaA-EGFP localized in actively growing hyphal tips, at the septa, and at junctions between the vesicle and phialides in an actin-dependent manner. This is the first study to implicate calcineurin in septum formation and conidiophore development of a filamentous fungus.

Source: Eukaryotic Cell

DOI: 10.1128/ec.00200-08

Authors: Praveen Rao Juvvadi, Jarrod R. Fortwendel, Nadthanan Pinchai, B. Zachary Perfect, Joseph Heitman, William J. Steinbach

Institution: Duke Medical Center

Language: English

Topic: Fungal and yeast genetics research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: diamond

Funders: Children's Miracle Network Hospitals, National Institutes of Health, National Institute of Allergy and Infectious Diseases

Award: G251155767