Detection of Nonnucleoside Reverse‐Transcriptase Inhibitor–Resistant HIV‐1 after Discontinuation of Virologically Suppressive Antiretroviral Therapy
Year: 2008
Type: article
Study design: Observational Study
Abstract: Using standard and ultrasensitive techniques, we detected nonnucleoside reverse-transcriptase inhibitor-associated resistance mutations in 11 (20%) of 54 subjects who discontinued virologically suppressive nonnucleoside reverse-transcriptase inhibitor-containing antiretroviral therapy. Resistance was detected in 45% and 14% of subjects with a baseline human immunodeficiency virus type 1 RNA level of 51-400 copies/mL and <or=50 copies/mL, respectively. Mutations remained detectable for at least 48 weeks in some subjects.
Source: Clinical Infectious Diseases
DOI: 10.1086/589867
Institutions: University of California, San Francisco, University of Pittsburgh, Harvard University, Tufts University, Baystate Medical Center, University of North Carolina at Chapel Hill, University of Washington, University at Buffalo, State University of New York, Vanderbilt University, National Institutes of Health, National Cancer Institute
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: ADULT AIDS CLINICAL TRIALS UNIT (AACTU), G1033683653, G1065691059, G115468880, G1331000642, COLUMBIA-ADARC-CORNELL AIDS CLINICAL TRIALS UNIT, G1544706747, G1586133245, G161582775, G1621430908, G1819583291, G1939027404, G1976846336, G2069435444, AIDS CLINICAL TRIALS UNIT, G251702431, G2709153970, ADULT AIDS CLINICAL TRIALS UNIT, General Clinical Research Center, ADULT AIDS CLINICAL TRIALS UNIT, G2987980373, G299859194, G320389021, G3206835426, ADULT AIDS CLINICAL TRIALS UNIT, G3277483280, G3508418089, ADULT AIDS CLINICAL TRIALS UNIT (ACTU), G3604395871, ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM FOR AIDS, G3955098203, ADULT AIDS CLINICAL TRIALS UNIT, GENERAL CLINICAL RESEARCH CENTER, General Clinical Research Center, Etiology of mastitis in HIV-1 infected women, AIDS CLINICAL TRIALS UNIT, G4208335746, General Clinical Research Center, G4699718705, ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM IN AIDS, G5364003616, ADULT ACTG CENTRAL GROUP, G556419284, VANDERBILT ADULT AIDS CLINICAL TRIALS UNIT, Statistical and Data Management Center for the AIDS Clinical Trials Group, General Clinical Research Center, ADULT AIDS CLINICAL TRIAL UNIT, G6103943158, SAN DIEGO AIDS CLINICAL TRIAL UNIT, G6477019531, AIDS CLINICAL TRIALS UNIT, AIDS CLINICAL TRIALS GROUP - ACTU, G724937252, G7416649483, HAWAII ACTU - ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM, NORTHWESTERN ADULT AIDS CLINICAL TRIALS UNIT, G766489020, ADULT AIDS CLINICAL TRIALS UNIT, ADULT AIDS CLINICAL TRIALS UNIT, ADULT THERAPEUTIC CLINICAL TRIALS PROGRAM FOR HIV/AIDS, University of Washington/Fred Hutch Center for AIDS Research, Statistical and Data Management Center (SDMC), Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (ACTG), The University of North Carolina Center for AIDS Research, ADULT AIDS CLINICAL TRIALS UNIT, G939730012, G964886957
OpenAlex ID: W2141581406