Year: 2015
Type: review
Abstract: Toxoplasmosis is the clinical and pathological consequence of acute infection with the obligate intracellular apicomplexan parasite Toxoplasma gondii. Symptoms result from tissue destruction that accompanies lytic parasite growth. This review updates current understanding of the host cell invasion, parasite replication, and eventual egress that constitute the lytic cycle, as well as the ways T. gondii manipulates host cells to ensure its survival. Since the publication of a previous iteration of this review 15 years ago, important advances have been made in our molecular understanding of parasite growth and mechanisms of host cell egress, and knowledge of the parasite's manipulation of the host has rapidly progressed. Here we cover molecular advances and current conceptual frameworks that include each of these topics, with an eye to what may be known 15 years from now.
Source: Annual Review of Microbiology
Language: English
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
Awards: G2069866550, Apicomplexan Drug Target Discovery, Organization of Toxoplasma invasion and cell division by EF-hand proteins, G5016500693, Molecular and Informatics methods for whole-genome mutational profiling, Cytoskeleton scaffold assembly in Toxoplasma gondii, Control of Toxoplasma gondii Growth by the Host Cell Transcription Factor HIF1, The role of the DOC2.1 protein in Toxoplasma gondii Ca2+- dependent exocytosis, Molecular Discovery and Characterization within Toxoplasma Egress Pathways
OpenAlex ID: W2141592854