Work

Potential Efficacy of Citicoline as Adjunct Therapy in Treatment of Cerebral Malaria

Year: 2013

Type: article

Abstract: Cerebral malaria (CM) is characterized by a dysregulated immune response that results in endothelial membrane destabilization and increased microparticle (MP) production. Citicoline (CTC) is a membrane stabilizer used for the treatment of neurological disorders. We evaluated the efficacy of CTC as adjunct therapy to aid recovery from experimental CM. We show that CTC reduces MP production in vitro; in combination with artesunate in vivo, confers partial protection against CM; and prolongs survival.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.02591-12

Authors: Fatima El-Assaad, Valery Combes, Georges Emile Raymond Grau, Ronan Jambou

Institutions: The University of Sydney, Institut Pasteur de Madagascar

Language: English

Topic: Malaria Research and Control

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2141670360