Work

Efficacy of Single-Dose Liposomal Amphotericin B or Micafungin Prophylaxis in a Neutropenic Murine Model of Invasive Pulmonary Aspergillosis

Year: 2008

Type: article

Abstract: In a neutropenic murine model of invasive pulmonary aspergillosis, prophylaxis with single doses of liposomal amphotericin B or micafungin at >or=5 mg/kg of body weight improved animal survival and suppressed the lung fungal burden for up to 7 days after infection, demonstrating the potential utility of infrequent dosing with these antifungals.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.00715-08

Authors: Russell E. Lewis, Nathaniel D. Albert, Dimitrios P. Kontoyiannis

Institutions: Texas Medical Center, The University of Texas MD Anderson Cancer Center, University of Houston

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Astellas Pharma