Dietary Phosphatidylcholine Intake and Type 2 Diabetes in Men and Women

Year: 2015

Type: article

Abstract: Recent studies have related plasma lev-els of gut microbiota metabolites of di-etary phosphatidylcholine to risk of cardiovascular disease (1,2). Choline from dietary phosphatidylcholine can be converted by gut microbes to form trimethylamine, which is then ab-sorbed and oxidized in the liver to form trimethyamine oxidase (3). Diet is the primary source of gut microbiota metabolites; however, little is known about the association between dietary phosphatidylcholine and risk of type 2 diabetes (T2D). We extracted data with dietary intake from three ongoing cohorts: the Nurses’ Health Study (NHS), NHS II, and the Health Professionals Follow-Up Study (HPFS). We excluded participants with diabetes (n5 5,466), cardiovascular dis-ease (n5 3,655), cancer (n5 8,675), or implausible dietary data (n 5 4,009) at baseline, leaving 203,308 men and women for analysis (NHS: 73,128; NHS II: 88,516; HPFS: 41,664). Dietary phos-phatidylcholine was estimated by a valid food-frequency questionnaire (4), with approximately 130 food items adminis-tered every 2 or 4 years combined with the phosphatidylcholine contents from the U.S. Department of Agriculture da-tabase

Source: Diabetes Care

DOI: 10.2337/dc14-2093

Authors: Yanping Li, Dong D. Wang, Stephanie E. Chiuve, JoAnn E. Manson, Walter C. Willett, Frank B. Hu, Lu Qi

Institutions: Harvard University, Brigham and Women's Hospital

Language: English

Topic: Nutritional Studies and Diet

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: American Heart Association, United States-Israel Binational Science Foundation, National Institutes of Health, National Heart, Lung, and Blood Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases

OpenAlex ID: W2142233821