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1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

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Year: 2010
Type: article
Source: Bioorganic & Medicinal Chemistry Letters
DOI: 10.1016/j.bmcl.2010.12.042
Authors: Sampath-Kumar Anandan, Heather Kay Webb, Dawn Chen, Yi-Xin (Jim) Wang, Basker R. Aavula, Sylvaine Cases, Ying Cheng, Zung N. Do, Upasana Mehra, Vinh Tran, Jon Vincelette, Joanna Waszczuk, Kathy White, Kenneth R. Wong, Le-Ning Zhang, Paul D. Jones, Bruce D. Hammock, Dinesh V. Patel, Randall Whitcomb, D. Euan MacIntyre, James Sabry, Richard Gless
Institutions: UC Davis Comprehensive Cancer Center, University of California, Davis
Language: English

Topic: Eicosanoids and Hypertension Pharmacology
Subfield: Biochemistry
Field: Biochemistry, Genetics and Molecular Biology
Domain: Life Sciences
SDG: Good health and well-being

Open Access status: green

Funders: National Heart, Lung, and Blood Institute, National Institute of Environmental Health Sciences
Awards: Epoxide hydrolase inhibition:End-Stage Renal Disease, Hydrolytic enzymes in the metabolism of toxins
OpenAlex ID: W2142310620
FWCI: 2.638
Cites: 58
Cited by: 72
Related to: 10
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