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The transcription factor GATA6 is essential for early extraembryonic development

Year: 1999

Type: article

Abstract: The gene coding for the murine transcription factor GATA6 was inactivated by insertion of a beta-galactosidase marker gene. The analysis of heterozygote GATA6/lacZ mice shows two inductions of GATA6 expression early in development. It is first expressed at the blastocyst stage in part of the inner mass and in the trophectoderm. The second wave of expression is in parietal endoderm (Reichert's membrane) and the mesoderm and endoderm that form the heart and gut. Inactivation leads to a lethality shortly after implantation (5.5 days postcoitum). Chimeric experiments show this to be caused by an indirect effect on the epiblast due to a defect in an extraembryonic tissue.

Source: Development

DOI: 10.1242/dev.126.4.723

Authors: Manoussos Koutsourakis, An Langeveld, Roger Patient, Rosa Beddington, Frank Grosveld

Institutions: Erasmus University Rotterdam, King's College London, National Institute for Medical Research

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Nederlandse Organisatie voor Wetenschappelijk Onderzoek

OpenAlex ID: W2142330433

FWCI: 6.895

Cites: 57

Cited by: 461

Related to: 9