Work

In Vivo Optical Imaging of Amyloid Aggregates in Brain: Design of Fluorescent Markers

Year: 2005

Type: article

Abstract: Routine diagnostics and studies of Alzheimer's disease might benefit form the noninvasive optical imaging of amyloid-β plaques in the brain. A rational design strategy for in vivo amyloid-imaging agents that enter the brain and selectively stain amyloid plaques is presented (see picture), and properties of a promising lead biomarker candidate are reported.

Source: Angewandte Chemie International Edition

DOI: 10.1002/anie.200500845

Authors: Evgueni E. Nesterov, Jesse Skoch, Bradley T. Hyman, William E. Klunk, Brian J. Bacskai, Timothy M. Swager