The effect of high altitude and other risk factors on birthweight: independent or interactive effects?
Year: 1997
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: This study examined whether the decline in birth-weight with increasing altitude is due to an independent effect of altitude or an exacerbation of other risk factors. METHODS: Maternal, paternal, and infant characteristics were obtained from 3836 Colorado birth certificates from 1989 through 1991. Average altitude of residence for each county was determined. RESULTS: None of the characteristics related to birthweight (gestational age, maternal weight gain, parity, smoking, prenatal care visits, hypertension, previous small-for-gestational-age infant, female newborn) interacted with the effect of altitude. Birthweight declined an average of 102 g per 3300 ft (1000 m) elevation when the other characteristics were taken into account, increasing the percentage of low birthweight by 54% from the lowest to the highest elevations in Colorado. CONCLUSIONS: High altitude acts independently from other factors to reduce birthweight and accounts for Colorado's high rate of low birthweight.
Authors: G M Jensen, L G Moore
Institution: University of Colorado Denver
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
Award: Adaptation to Hypoxia
OpenAlex ID: W2142359591
