Work

Molecular evolution of the Escherichia coli chromosome. II. Clonal segments.

Year: 1988

Type: article

Abstract: Remarkable sequence similarities in the trp region among Escherichia coli strains of diverse natural origins imply the existence of worldwide clones of very recent origin. This in turn implies a low rate of fixation of new universally favorable alleles, which carry adjacent stretches of chromosome to high frequency. These clonal segments begin as entire chromosomes; recombination shortens them progressively by substituting less closely related homologous DNA. The rate of this recombination, comprising the introduction of a homologous chromosomal fragment to a cell and the replacement of part of the original chromosome, is estimated from observations.

Source: Genetics

DOI: 10.1093/genetics/120.2.359

Authors: R Milkman, A Stoltzfus

Institution: University of Iowa

Language: English

Topic: Evolution and Genetic Dynamics

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: National Institute of General Medical Sciences

Award: DNA SEQUENCE VARIATION IN E. COLI AND IN B SUBTILIS