Work

Apparent prevention of neural tube defects by periconceptional vitamin supplementation.

Year: 1981

Type: article

Abstract: An earlier preliminary paper is expanded. Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of per conceptional vitamin supplementation. Two hundred mothers attending five centres were fully supplemented (FS), 50 were partially supplemented (PS), and 300 were unsupplemented (US). Neural tube defect recurrences in the study pregnancies were 1 (0.5%), in FS, none in PS, and 13 (4%) in US mothers. The difference in outcome between FS and US mothers is significant. The most likely explanation is that supplementation has prevented some neural tube defects, but further studies are needed.

Source: Archives of Disease in Childhood

DOI: 10.1136/adc.56.12.911

Authors: R W Smithells, S Sheppard, C J Schorah, M J Seller, N C Nevin, R Harris, A P Read, D W Fielding

Institutions: University of Leeds, Queen's University Belfast, Guy's Hospital, University of Manchester

Language: English

Topic: Folate and B Vitamins Research

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2142465069

FWCI: 23.31

Cites: 17

Cited by: 381

Related to: 10