Alteraciones genómicas estructurales y funcionales de las células tumorales en cánceres esporádicos: el modelo del cáncer mamario
Year: 2013
Type: article
Abstract: Recently, chronic-degenerative diseases can be studied though a structural and functional genome point of view. Among these diseases, cancer is the main group studied in a subcelular/genomic/epigenomic and proteomic context. The second and third generation of sequencing technologies used in genomic studies have improved the resolution and in massive whole-gene simultaneous analysis of the phenotypical cell processes. Many of these molecular characteristics are used as physiopathologic indicators or biomarkers of phenotype cell processes. Each tumor is particularly transformed by cuasi-specific molecular changes. Some of the biomarkers of specific tumors, have been validated as biological behavioral indicators, which are associated to prognostic or predictive clinical factors, the most significant example of these biomarker is the MammaPrint, a simplified gene expression array used with prognostic utility in early breast cancer patients. The identification of some biomarkers has favoured the targeted drugs success, such as imatinib in CML and in GISTs pa-
Source: Gaceta Mexicana de Oncología
Language: Spanish
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: diamond
OpenAlex ID: W2142469479